1009 Sensitization to Three Domestic Mites in Patients with Adverse Food Events to Shellfish

Sunday, 6 December 2015
Ivanka Trump Ballroom (Trump National Doral)

Mirta Alvarez Castello, MD , Allergology Service, University Hospital Calixto García, Havana, Cuba

Raúl Lázaro Castro Almarales, MD, MSc , Allergens Department, National Center of Bioproducts, Mayabeque, Cuba

Alexis Labrada, PhD , Allergens, Biocen, Mayabeque, Cuba

Maytee Mateo, MSc , Allergens, Biocen, Mayabeque, Cuba

Background: Food allergy to shellfish affects a large population all over the world. It is well established that most allergic patients to shellfish present sensitization to mites, as well. The aim of this study was to assess the sensitization to three species of house dust mites in adults with food allergy to shellfish

 Method:  A descriptive and cross-sectional study was carried out.  The study included 25 adult patients with allergic reactions to food shellfish. Mean age: 37 (range 22-62 years). Six cases had occupational exposure, and one of them had food-dependent exercise-induced anaphylaxis.   For each subject, a clinical and  occupational history was compiled and skin testing was performed. Skin Prick Test (SPT) was performed with standardized allergen extracts (BIOCEN, Cuba) of Dermatophagoides pteronyssinus, D. siboney and Blomia tropicalis at 20 000 BU/mL.

Results: 100% subjects showed a positive response to Dermatophagoides mites by SPT. Twenty subjects had personal history of atopy (80%).  Shrimp was the most  common seafood involved.  The most reported symptoms after food consumption were cutaneous (84%) followed by gastrointestinal (76 %) and respiratory symptoms (60 %), mostly, dyspnea. The largest mean wheal size was reported to Blomia tropicalis (5.82mm), followed by D. siboney (4.97mm). 100 % of patients that were occupationally exposed showed positive response to shrimp and lobster. A positive and strong correlation was found between reaction size to shrimp and lobster.

Conclusion: There is a high prevalence of sensitization to mites in adults with allergic reactions to shellfish. The co-existent atopic disease, sensitization to mites and occupational exposure are factors to consider in food allergy to shellfish.

Learning Objectives:
To identify the sensitization to three domestic mites in adults with food allergy diagnosis caused by shellfish and to determine the allergic symptoms in these patients.