Thursday, 15 October 2015
Hall D1 Foyer (Floor 3) (Coex Convention Center)
Tomomitsu Hirota, PhD
,
Laboratory for Respiratory and Allergic Diseases, Riken, Yokohama, Japan
Mayumi Tamari, MD., PhD
,
Riken Center for Integrative Medical Sciences, Kanagawa, Japan
Motohiro Ebisawa, MD, PhD
,
Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Sagamihara, Japan
Sakura Sato, MD
,
Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Sagamihara, Japan
Takanori Imai, MD
,
Department of Pediatrics, National Sagamihara Hospital, Kanagawa, Japan
Teruaki Matsui
,
Aichi Children's Health and Medical Center, Obu, Japan
Komei Ito
,
Aichi Children's Health and Medical Center, Obu, Japan
Satoru Doi
,
Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, Habikino, Japan
Noriyuki Yanagida, MD
,
Pediatrics, Sagamihara National Hospital, Sagamihara, Japan
Background: The prevalence of food allergy (FA) has increased over the past two decades, particularly in the developed countries. FA is an adverse health effect arising from a specific immune response that occurs reproducibly on exposure to a given food. Recent GWASs have shown that IL13 gene locus on chromosome 5q31 is associated with bronchial asthma and atopic dermatitis; however influences of genetic variations in the IL13 gene on susceptibility to FA are unclear.
Objective: To investigate the association between variants of IL13 gene and FA and FA related phenotypes in the Japanese population.
Methods: We re-sequenced the IL13 gene region by PCR-directed sequencing. Four tag SNPs were selected using the Tagger algorithm and genotyped by Invader methods. We performed association studies of FA using two independent Japanese populations (1st population, 603 cases and 1004 controls; 2nd population 282 cases and 904 controls). Among the 1st FA population, a total of 182 subjects have bronchial asthma.
Results: We found a total of 17 variants including a non-synonymous substitution (rs20541; Arg144Gln). We observed a significant association at rs20541 (meta-analysis, combined P = 1.33×10-7; OR, 1.39; 95% CI, 1.23-1.57). In further analyses of patient subgroups, we observed a strong association between rs1295686 and FA with bronchial asthma (P = 2.44×10-6; OR, 1.74; 95% CI, 1.38-2.19).
Conclusions: rs1295686 of IL13 gene is significantly associated with FA in the Japanese population. Although further genetic and functional analyses are needed, our findings could help elucidate common genetic factors for bronchial asthma, atopic dermatitis, and FA.
