Objective: To evaluate the safety of meloxicam as analgesic and anti-inflammatory alternative for patients who have experienced a hypersensitivity reaction to a NSAID.
Methods: We retrospectively evaluated patients who had reported an adverse reaction to several drugs of the NSAID group and had been subjected to a challenge with Meloxicam, between 2010-2013, in our allergy service in Medellin, Colombia.
Results: A total of fifty-seven patients reported hypersensitivity reactions to two or more NSAIDs, nineteen patients reported an anaphylactic reactions. All were challenged with meloxicam, thirty-six patients with incremental doses of 1.5, 3, 4.5 and 6 mg for a total dose of 15 mg, seventeen patients with a total dose of 7.5 mg, one patient to 10mg and one patient 5 mg for their age. Fifty-five patients had a negative test challenge, two patients (3.5%) with a positive challenge, both with skin symptoms (hives and angioedema).
Conclusion: Meloxicam is an anti-inflammatory analgesic and safe alternative for patients who have experienced a hypersensitivity reaction to 2 or more NSAIDs.
References:
- Maria Jose Torres, Esther Barrionuevo, Marek Kowalski, Miguel Blanca. Hypersensitivity Reactions to Nonsteroidal Anti-Inflammatory Drugs. Immunol Allergy Clin N Am 34 (2014) 507–524
- G.E. C¸elik, F.Ö. Erkekol, Ö. Aydın, Y.S. Demirel, Z. Mısırlıgil. Are drug provocation tests still necessary to test the safety of COX-2 inhibitors in patients with cross-reactive NSAID hypersensitivity?. Allergol Immunopathol (Madr). 2013;41(3):181-188