Tuesday, 9 December 2014
Exhibition Hall-Poster Area (Sul America)
Besa Gacaferri Lumezi, PhD candidate
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Department of Physiology and Immunology, Medical Faculty, University of Prishtina, Prishtina, Kosovo
Violeta Lokaj Berisha, PhD candidate
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Department of Physiology and Immunology, Medical Faculty, University of Prishtina, Prishtina, Kosovo
Hatixhe Latifi Pupovci, Assoc. Prof.
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Department of Physiology and Immunology, Medical Faculty, University of Prishtina, Prishtina, Kosovo
Aferdita Goci Uka, PhD candidate
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Child and Adolescent Mental Health Center, University Clinical Center of Kosova, Prishtina, Kosovo
Natyra Karahoda Gjurgjeala, Prof.
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Department of Physiology and Immunology, Medical Faculty, University of Prishtina, Prishtina, Kosovo
Ganimete Minci Bejtullahu, Assoc.Prof.
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Department of Physiology and Immunology, Medical Faculty, University of Prishtina, Prishtina, Kosovo
Luljeta Ahmetaj, PhD candidate
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Department of Physiology and Immunology, Medical Faculty, University of Prishtina, Prishtina, Kosovo
Teuta Morina, student
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Medical Faculty, University of Prishtina, Prishtina, Kosovo
Hirsutism is defined as the excessive growth of thick dark hair in an androgen-dependent pattern where hair growth in women is usually minimal or absent, affecting between 5% and 15% of women. The most common cause of androgen excess is the polycystic ovary syndrome (PCOS), with 21-hydroxylase– deficient nonclassic adrenal hyperplasia, the hyperandrogenic insulin-resistant acanthosis nigricans syndrome, androgen-secreting tumors, and androgenic drug intake occurring less frequently. Not all hirsute patients have evidence of detectable androgen excess, as 5–15% of these women have “idiopathic hirsutism.’’
Autoimmune disease of the adrenal gland appears very rarely and is observed only after 90% of the adrenal gland is destroyed. Autoimmune adrenalitis can be primary, with no known cause, or secondary autoimmune disease caused by congenital adrenal hyperplasia.
We present the case of a 22-year-old girl with hirsutism expressed especially in the body. She underwent evaluation to identify the etiology. ACTH, testosterone and progesterone were within normal range, while Androstenedione, 17-OH-progesterone and SHBG levels were increased. The level of antibodies for 21 hydroxylase (21OHAb) was established, which shows adrenal hereditary autoimmune origin, without adrenal insufficiency. Objective examination confirmed the presence of atopy with skin-prick test positive to house dust with Dermatophagoides pteronyssinus and Dermatophagoides farinae. Further research is needed for establishing the link between autoimmune disease with atopic diseases.
