Methods: cluster allergen immunotherapy with 4-5 allergen doses of House Dust Mites ( HDM) of variable concentration at interval of one hour in 12hrs observation period
Results: in 20 %developed systemic reaction & in 80 % it is safe and well tolrated to achive the maintinence dose of allergen extracts of House Dust Mites ( HDM)
Conclusions: allergen extract of house dust mites(HDM) by cluster immunotherapy is safe and have better compliance
introduction:The House Dust Mites is a major cause of perennial allergic BR ASTHMA.Allergen immunotherapy is the only therapy which can modify the natural course of disease .The success of allergen immunotherapy is dose- dependant as well the quality of extract used and compliance by the patient. The conventional subcutaneous immunotherapy(SCIT) is a slow treatment that often leads to poor compliance or discontinuation of treatment
The safety of cluster allergen immunotherapy has been studies in sixty five patients of perennial allergic bronchial asthma. Maximum maintenance dose of House Dust Mites ( HDM ) extracts was administered to patients by subcutaneous injection with designed protocol of Cluster immunotherapy as per maximum tolerance of patients with variable concentration of maintainence dose at interval of one hr in a 12hr observation period and subsequent doses prescribed at minimum duration from 5-7 days to achieve maximum tolerence dose (MTD) or optimum dose in 6-8 weeks.All 65 patients of perennial bronchial asthma received the planned maximal dose of House dust mite extracts of D-farinae & D-pteronyssinus . Systemic reaction was found in 20 % of the patient which was well controlled after administration of injection adrenaline .No severe or near fatal reactions was found in 80 % of the patients after administration of maximum tolerence dose (MTD) in duration of six weeks . Cluster allergen immunotherapy (CIT) is a useful therapeutic option , safe and well tolerated by our patients in perennial allergic bronchial asthma who are,immunologically significant Sensitive to House Dust Mites .