Saturday, 17 October 2015
Hall D1 Foyer (Floor 3) (Coex Convention Center)
Ji Hye Kim, MD
,
Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, South Korea
Moon Gyeong Yoon, M.S
,
Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, South Korea
Hye Min Jung, M.S.
,
Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, South Korea
Ga Young Ban, MD
,
Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, South Korea
Young Min Ye, MD, PhD
,
Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, South Korea
Hae-Sim Park, MD, PhD
,
Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, South Korea
Yoo Seob Shin, MD, PhD
,
Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, South Korea
N-acetylcysteine(NAC) is widely used drug as a mucolytic in chronic respiratory diseases, an antidote in acetaminophen overdose and a protective agent for renal function in contrast-induced nephropathy. NAC is considered a well-tolerated and safe medication and no serious adverse reactions have been reported. Here we report a case of contact dermatitis to NAC.
A32-year-old woman presented with a symptoms of eczematous skin lesion on exposed area of hands, arms and face for several weeks. She was suffering with symptoms of her rash and itching sensation on the lesion. The patient was diagnosed as allergic rhinitis sensitized to house dust mite, but the symptoms were not bothersome. She had a previous history of drug allergy to non-steroid anti-inflammatory drugs. She was a nurse working in general ward of a tertiary hospital. Her symptoms had developed since she started working in the ward, mixing NAC and various antibiotics with normal saline. Serum total IgE level was not increased (69KU/L) and skin prick test revealed sensitization to various inhalant allergens including house dust mites. Serum specific IgE and skin prick test to antibiotics were negative. Intradermal test with NAC at 1mg/ml and 10mg/ml showed a positive result, both immediate and late reactions (after 48hours). Patch test using NAC also revealed a positive result after 96 hours. Serum specific IgE, IgG1 and IgG4 to NAC-human albumin conjugate were not detected by enzyme-linked immunosorbent assay. We report a case of allergic contact dermatitis due to NAC which was exposed in the workplace.
