Methods: Retrospective review with prospectively collected data. 221 CRS patients who underwent endoscopic sinus surgery (ESS) were enrolled. All tissues were microscopically examined for the presence of eosinophilia (10≥high power field). Blood eosinophil count and serum levels of total IgE, specific IgE to TSST-1 and eosinophil cationic protein (ECP) using ImmunoCAP were analyzed.
Results: Fifty six CRS without NP (47 non-eosinophilic and 9 eosinophilic) and 165 CRS with NP (114 non-eosinophilic and 51 eosinophilic) patients were included. The level of blood eosinophil count, total IgE and ECP were not significantly different, but serum specific IgE to TSST-1 was different between CRS with NP and without NP (p=0.26). Positive rate of serum specific IgE to TSST-1 was higher in Eosinophilic CRS with NP (54.9%) than CRS without NP (23.2%) and noneosinophilic CRS with NP (25.4%) (p=0.001).
Conclusions: This study demonstrates higher positive rate of serum specific IgE to TSST-1 in patients with eosinophilic CRS with NP but not in noneosinophlic CRS with NP. Preoperative examination of serum specific IgE to TSST-1 can help the prediction of eosinophilic NP that has been shown to higher recurrence rate after ESS.