Saturday, 17 October 2015
Hall D1 Foyer (Floor 3) (Coex Convention Center)
Woo-Sung Chang, PhD
,
Division of Allergy and Chronic Respiratory Diseases, Center for Biomedical Sciences, Korea National Institute of Health, Korea Center for Disease Control and Prevention, Cheongju, South Korea
Hye-Sun Lim, PhD
,
Division of Allergy and Chronic Respiratory Diseases, Center for Biomedical Sciences, Korea National Institute of Health, Korea Center for Disease Control and Prevention, Cheongju, South Korea
Dankyu Yoon, PhD
,
Division of Allergy and Chronic Respiratory Diseases, Center for Biomedical Sciences, Korea National Institute of Health, Korea Center for Disease Control and Prevention, Cheongju, South Korea
Ji-Hye Do
,
Division of Allergy and Chronic Respiratory Diseases, Center for Biomedical Sciences, Korea National Institute of Health, Korea Center for Disease Control and Prevention, Cheongju, South Korea
Yeon-Seop Kim
,
Division of Allergy and Chronic Respiratory Diseases, Center for Biomedical Sciences, Korea National Institute of Health, Korea Center for Disease Control and Prevention, Cheongju, South Korea
Jeom-Kyu Lee, PhD
,
Division of Allergy and Chronic Respiratory Diseases, Center for Biomedical Sciences, Korea National Institute of Health, Korea Center for Disease Control and Prevention, Cheongju, South Korea
Eun-Jin Kim, PhD
,
Division of Allergy and Chronic Respiratory Diseases, Center for Biomedical Sciences, Korea National Institute of Health, Korea Center for Disease Control and Prevention, Cheongju, South Korea
Background:Allergic diseases are mainly mediated by immune responses with IgE antibodies specific for allergens and orchestrated by various immunological factors including immune cells and cytokines. It was known that the level of total IgE, helper T cells and some cytokines were associated with allergic inflammation and disease development. Evaluation of the correlation between them is needed to examine their possibilities as a reference factor for the diagnosis and monitoring of allergic diseases.
Methods:We previously investigated the serum level of total IgE, 22 allergy-related cytokines, and the ratio of Th1/Th2 cells respectively in both normal individuals and allergic patients. Each factor was compared in normal and allergic participants to examine their significant difference. The correlation of total IgE with other immunological factors was investigated by various statistical analysis using integrated results of each factors.
Results:The serum level of total IgE in allergic patients was significantly higher than normal subjects (265.6 vs. 47.16 kU/L, p<0.0001). Th1 cell percentage was also different (6.54 vs. 8.60, p=0.001), but Th2 cell percentage and Th1/Th2 ratio showed no significant difference between normal and allergic participants. Nine of 22 cytokines were analyzed in allergic patients and their levels increased in patients compared to normal individuals, particularly Platelet-Derived Growth Factor BB (PDGFBB) was much higher in allergic patients (1491.3 vs. 536.0 pg/ml, p<0.0001). By integrated analysis in all participants, total IgE had a significant correlation with Th1/Th2 ratio and Th2 cell percentage (p=0.02 and p=0.04, respectively).
Conclusion: In this study, we found that Th1 cell percentage decreased in allergic patients, supporting Th1 cells might be important roles in allergic responses. Our results also showed that PDGFBB could be responsible for allergic responses, suggesting its possibility as a reference factor for allergic diseases. We demonstrate that the correlation of total IgE with Th1/Th2 ratio and Th2 cell percentage might be relevant to corroborate the immunological function of Th2 cells for IgE-related responses.
