Oral allergy syndrome (OAS) may be the most common food-related allergy in adults. Even of OAS, pollen-food allergy is complicated because of cross-reactivity to proteins.
The ImmunoCAP ISAC（Immuno Solidphase Allergen Chip） allows detection of specific IgE to 112 molecular components from 51 allergenic sources. This new approach helps to clarify the molecular bases of primary sensitization and cross-reactivity phenomena. We used this approach to analyze allergen component comprehensively.
Methods:
We retrospectively analyzed sera from 11 patients who had been examined based on suspicion of allergy at the Department of Dermatology of the Osaka University.
Of the 11 patients, 10 patients have symptom such as pruritus or tingling of the lips, oral mucosa, and throat. One patient did not have symptom.
ImmunoCAP ISAC was used for screening allergen component and compared with other tests results such as skin prick test. To specigy the antigen, ELISA and western blot and blood testing were also performed.
Results:
This test is useful for the cross reaction of an allergy patient sensitized to a large number of allergens, the grasp of the sensitization pattern with the common antigen.
Younger patients, who are under 14y.o, had the lower number of positive components than that of over 14y.o.
Tick, cat and dog related components were characteristic patients with dermatitis. Result of exclude the tick, cat and dog related components, number of positive components of patients with AD or eczema (contact dermatitis and PPP) were higher than with no dermatitis.
Conclusion:
We found that the both age and dermatitis were the factors influencing to the causative factors in OAS.
Our finding suggest that the number of the positive components was higher in the subject accompanied with AD compared to the subjects without AD. Thus, it assumed that the subjects with AD might be highly susceptible to OAS.