Cases: First case is a 35-year-old man who visited our emergency room complaining abdominal pain, diarrhea, and nausea for the last 5 days after upper respiratory infection. He had an experience of being treated for EG and pancreatitis with ascitis 10 years ago. In his laboratory finding, peripheral WBC count was 21,600 mm3with 60% eosinophilia. After endoscopic study and abdominal computed tomography, he was diagnosed with EG and referred to allergic clinic. He didn’t complain any food related allergy symptoms except intermittent mild rhinitis symptoms and cough. He exhibited elevated serum total IgE level and positive responses to house dust mite and Japanese hop pollen on skin prick test. Lung function test showed obstructive pattern with positive response to bronchodilator. Finally, he was diagnosed as EG with allergic rhinitis and bronchial asthma. He was treated with prednisolone therapy for EG, recommended to take anti-allergic medication as well.
The second case is a 42-year-old female with nausea and indigestion of several months. She has been treated for eosinophilic gastritis on the endoscope for one month at another hospital. But, the symptoms were persisted and more aggravated after milk ingestion. Moreover, urticarial was newly developed form 3 weeks ago. WBC count was 6750 mm3with 5.5 % eosinophilia. Skin prick test showed positive response to house dust mite and grass pollen. High serum specific IgE levels to milk were noted. She was diagnosed as EG with food allergy and urticaria. She was recommended avoiding milk with oral antihistamine therapy. Three months after food restriction and medication, her symptom was improved and endoscopic study was normal.
Conclusion: We report two cases of EG associated with respiratory and food allergy, respectively. Although EG has various clinical manifestation, our report suggests that the possibility of co-existence of EG and allergic disease should be considered.