previously investigated, but there are still some issues to be clarified. The aim of this
study was to assess the link between AHR to mannitol and atopy in asthmatic
Methods: We evaluated 70 children with asthma, aged six to 16-years-of-age,using skin
prick tests (SPTs), serum total and specific immunoglobulin E (IgE) levels. Pulmonary function tets were performed : baseline, postbronchodilator inhalation and mannitol inhalation. The response to mannitol was expressed as the dose causing a 15% decrease in forced expiratory volume in one second (FEV1) (PD15). Atopy as the presence of at least one positive allergen-specific IgE test result (IgE ≥0.35 kU/l) or a finding on SPT.
Results: 49 subjects (70%) with asthma showed a positive result in mannitol bronchial provocation test (BPT). In the mannitol BPT-positive group, 43 (43/49, 87.8%) subjects were diagnosed to atopy, In the mannitol BPT-negative group, 20 (20/21, 95.2%) subjects were diagnosed to atopy. There was no significant difference in atopy prevalence between mannitol BPT-positive and BPT-negative group. We found a correlation between mannitol PD15 and serum total IgE (r= -0.326; p=0.031).
In children with pediatric asthma, we could not find a significant correlation between AHR to mannitol and atopy prevalence.