Method : Respiratory fuction tests were conducted on 302 patients (193 female-109 male, totally with age group of 18-79) who applied to Chest Diseases Polyclinics between January-May 2015. Patients were classified as mild, moderate and severe due to GINA 2014 criteria. Vitamin A, vitamin D, vitamin E, folic acid and vitamin B12 levels were investigated. Statistically, Mann Whitney U, Kruskall Wallis-H and Post-Hoc tests were applied.
Results: In all age groups, vitamin A and vitamin D values of females were significantly lower than those of males (p<0.05). In patients of age 29 and lower, folic acid values were significantly low. Due to vitamin A, vitamin D, vitamin E, vitamin B12 and folic acid, no statistically significant difference was detected among astmatic levels of patients enrolled in the study (p>0.05).
Conclusions: Beside physiopathologic changes during astma, evidence of free oxygen radical release out of inflammatory cells and decrease in antioxidant levels give an impression of oxidant-antioxidant disequilibrium role in astmatic pathogenesis. As a defence mechanism of body against oxydative stress, outsourcing of vitamins is therefore essential. Low values of vitamin A and vitamin D values in astmatic patients encourage astmatic symptom severity, in addition to exhaustion, fatigue, bone ache and eye diseases. Reinforcement of vitamins through nutrition and medication is believed to be useful in treatment of asthma.