Saturday, 17 October 2015
Hall D1 Foyer (Floor 3) (Coex Convention Center)
Hyunjung Hwang, MD
,
Division of Pulmonology and Allergy, Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, South Korea
Background: Studies evaluating whether allergy patients change their recognition of causal allergen, its avoidance, and allergen specific immunotherapy (SIT) during diagnosis and treatment of their diseases are relatively rare. The objective of this study is to evaluate those changes after skin prick test / intradermal test (SPT/IDT), nasal provocation test (NPT), and allergen-specific intralymphatic immunotherapy (ILIT) for causal allergen among patients with allergic rhinitis. Method: After informed consent, nine subjects with allergic rhinitis in whom allergens including D. farinae, D. pteronyssinus, cat hair, and dog hair/dander were proven to provoke their rhinitis symptoms by history taking, skin prick test, and measurement of serum specific IgE were asked to respond to the following questions: “Do you agree that allergen provokes allergic symptoms in daily life?”, “Do you agree that allergen avoidance can reduce allergic symptoms?”, and “Do you agree that allergen specific immunotherapy can reduce allergic symptoms?” Thereafter, they underwent SPT/IDT, NPT, and ILIT for their causal allergens. They were repeatedly asked to respond to those questions immediately after SPT/IDT, NPT, as well as 4 and 12 months after ILIT. Results: The agreement (%) to “Allergen provokes allergic symptoms in daily life” changed from 67.7 ± 34.2 to 79.3 ± 25.7 (after SPT/IDT), 85.7 ± 13.4 (after NPT), 93.1 ± 11.7 (4 months after ILIT), and 90.6 ± 12.9 (12 months after ILIT). The agreement (%) to “Allergen avoidance can reduce allergic symptoms” changed from 67.7 ± 34.2 to 82.2 ± 20.6 (after SPT/IDT), 82.1 ± 27.8 (after NPT), 90.9 ± 12.6 (4 months ILIT), and 90.6 ± 12.9 (12 months after ILIT). The agreement (%) to “Allergen specific immunotherapy can reduce allergic symptoms” changed from 65.6 ± 29.3 to 81.5 ± 15.5 (after SPT/IDT), 85.7 ± 19.7 (after NPT), 86.3 ± 23.3 (4 months after ILIT), and 81.3 ± 11.6 12 months after ILIT). Conclusion: Allergy skin test, nasal provocation, and SIT themselves can intensify patients’ recognition of causal allergen, its avoidance, and allergen-specific immunotherapy. Acknowledgement: This work was supported by the Gachon University Gil Medical Center (Grant number: 2013-11). We thank to ThermoFisher Scientific Korea for support in measuring serum total and allergen-specific IgE/IgG4 (ImmunoCAP®). For providing allergen extracts which were used for NPT, we also appreciate Research Center for Standardization of Allergic Diseases (RCSAD) of Yonsei University supported by a grant from the Korea Healthcare Technology R&D Project, Ministry of Health, Welfare & Family Affairs, Republic of Korea (A092076).