7-4OAS Usefulness of Exhaled Nitric Oxide for Evaluating Wheeze and Airway Hyperresponsiveness in Preschool Children

Friday, 16 October 2015: 11:45 - 12:00
Room R2 ABC (Floor 3) (Coex Convention Center)

Jung-Won Lee, MD , Kangbuk Samsung Hospital, Seoul, South Korea

Ji-Won Kwon, MD , Seoul National University Bundang Hospital, Seongnam, South Korea

Woo Kyung Kim , Seoul Paik Hospital, Seoul, South Korea

Hyung Young Kim, MD , Department of Pediatrics, Pusan National University Yangsan Hospital, Yangsan, South Korea

Hyo-Bin Kim, MD , Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, South Korea

Ju-Hee Seo, MD , Department of Pediatrics, Korea Cancer Center Hospital, Seoul, South Korea

So-Yeon Lee, MD , Department of Pediatrics, Hallym University Sacred Heart Hospital, Anyang, South Korea

Gwang-Cheon Jang, MD , Pediatrics, National Health Corporation Ilsan Hospital, Seoul, South Korea

Young-Ho Jung, MD , Department of Pediatrics, Bundang CHA Medical Center, CHA University School of Medicine, Seongnam, South Korea

Soo-Jong Hong, MD, PhD , Research Center for Standardization of Allergic Diseases, University of Ulsan College of Medicine, Seoul, South Korea

Byoung-Ju Kim, MD , Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH

Dae-Jin Song, MD , Pediatrics, Guro Hospital, Seoul, South Korea

Jung Yeon Shim, MD , Pediatrics, Kangbuk Samsung Hospital/Sungkyunkwan University School of Medicine, Seoul, South Korea

Objective: Fractional concentration of exhaled nitric oxide (FeNO) is a known marker of airway inflammation. The aims of this study were to evaluate FeNO, impulse oscillometry (IOS), and spirometry in preschool children and to investigate their relationship with wheeze and airway hyperresponsiveness (AHR). Methods: We performed a population-based, cross-sectional study with 561 children aged 5-6 years. A total of 544 children completed a modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire and eligible for the study. We measured FeNO, spirometry, methacholine bronchial provocation, and IOS. AHR was defined as the induction of a 20% decrease in FEV1 (PC20) by a methacholine concentration ≤ 8.0 mg/dL. Results: Children who had wheeze or AHR had higher FeNO levels than children without these symptoms. However, neither IOS nor spirometry parameters showed significant differences between children with wheeze or AHR and those without. FeNO was associated with AHR, whereas IOS or spirometry parameters showed no association. Mean FeNO levels were positively correlated with a dose-response slope for methacholine, but neither IOS nor spirometry parameters showed significant correlations. Conclusions: FeNO is a more sensitive measurement of AHR and wheeze than spirometry or IOS in preschool children.