3175 Association of Recurrent Wheeze with Lung Function and Airway Inflammation in Preschool Children

Friday, 16 October 2015
Hall D1 Foyer (Floor 3) (Coex Convention Center)

Ji-Eun Soh, MD , Pediatrics, Kangbuk Samsung Hospital, Seoul, South Korea

Ji-Won Kwon, MD , Seoul National University Bundang Hospital, Seongnam, South Korea

Hyung Young Kim, MD , Department of Pediatrics, Pusan National University Yangsan Hospital, Yangsan, South Korea

Ju-Hee Seo, MD , Department of Pediatrics, Korea Cancer Center Hospital, Seoul, South Korea

Byoung-Ju Kim, MD , Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH

Hyo-Bin Kim, MD , Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, South Korea

So-Yeon Lee, MD , Department of Pediatrics, Hallym University Sacred Heart Hospital, Anyang, South Korea

Gwang-Cheon Jang, MD , Pediatrics, National Health Corporation Ilsan Hospital, Seoul, South Korea

Dae-Jin Song, MD , Pediatrics, Guro Hospital, Seoul, South Korea

Woo Kyung Kim , Seoul Paik Hospital, Seoul, South Korea

Young-Ho Jung, MD , Department of Pediatrics, Bundang CHA Medical Center, CHA University School of Medicine, Seongnam, South Korea

Soo-Jong Hong, MD, PhD , Research Center for Standardization of Allergic Diseases, University of Ulsan College of Medicine, Seoul, South Korea

Jung Yeon Shim, MD , Pediatrics, Kangbuk Samsung Hospital/Sungkyunkwan University School of Medicine, Seoul, South Korea

Objective: Recurrent wheeze is one of the predictive markers of asthma in preschool children. The aims of this study were to investigate airway inflammation, lung function, airway hyperresponsiveness (AHR), and the prevalence of allergic rhinitis (AR) and atopic dermatitis (AD) in preschool children according to recurrent wheeze. Methods: We performed a population-based, cross-sectional study with 933 children aged 4-6 years. A total of 900 children completed a modified International Study of Asthma and Allergies in Childhood questionnaire and eligible for the study. We measured exhaled nitric oxide (eNO), spirometry, methacholine bronchial provocation, and impulse oscillometry. Recurrent wheeze was defined as having a lifetime wheeze more than 3 times. Results: The prevalence of recurrent wheeze was 13.4%. Children with recurrent wheeze showed higher prevalence of lifetime and current AR and lifetime AD, not current AD. Recurrent wheeze was associated with lifetime emergency room visit more than 1 time and history of more than one admission within 12 months due to wheezing episode. High eNO, post-bronchodilator change of R5Hz, and blood eosinophils as well as low FEF25-75% were associated with recurrent wheeze. However, dose response slope by methacholine test, prevalence of atopy or AHR, and serum IgE levels showed no significant differences between two groups. Conclusions: Recurrent wheeze in preschool children may be associated with lower lung function and airway inflammation, not with AHR or atopy.