Friday, 16 October 2015
Hall D1 Foyer (Floor 3) (Coex Convention Center)
Sedigheh Bahrami Mahneh, MSc
,
Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Masoud Movahedi, MD
,
Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
Arezou Rezaei, MSc
,
Research Center for Immunodeficiencies, Tehran University of Medical Sciences, Tehran, Iran
Maryam Sadr, MSc
,
Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran
Nima Rezaei, MD, PhD
,
Research Center for Immunodeficiencies, Tehran University of Medical Sciences, Tehran, Iran
Background: As of possible role of interleukin-9 (IL-9), a pro-inflammatory and Th2 cytokine, and interleukin-33 (IL-33), a member of IL-1 cytokine family, in pediatric asthma, this study was performed to measure IL-9 and IL-33 serum levels in pediatric patients with asthma.
Methods: In this study, 61 patients with asthma and 63 healthy age- and sex- matched subjects were enrolled. Serum levels of IL-9 and IL-33 were measured in asthmatic patients and healthy subjects by sandwich ELISA.
Results: Serum IL-9 level was significantly higher in patients group, compared to the controls (p=0.03). In addition, patients with severe asthma had significantly higher serum IL-9 levels, compared to the controls (p<0.001). Mean serum level of IL-33 asthmatic children was also significantly higher than the controls (p=0.02), which also showed statistically significant associated with the severity disease (p=0.02).
Conclusions: Elevated serum levels of IL-9 and IL-33 were found to be associated with pediatric asthma and the disease severity.
