Thursday, 15 October 2015
Hall D1 Foyer (Floor 3) (Coex Convention Center)
A 7-year-old boy with acute osteomyelitis in right distal tibia, was treated by the combination of intravenous (IV) vancomycin and cefotaxime. He was tolerable for the given treatment and rapidly improved. Persistent fever had occurred from the day 17th with pruritic, maculopapular rash on day 19th. Laboratory test performed on day 20th revealed marked eosinophilia. Under suspicion of DRESS syndrome, both IV antibiotics were stopped and oral prednisolone was given. Three days after the cessation of the antibiotics, fever and skin manifestations had rapidly improved. However, as soon as we retried IV cefotaxime, his skin manifestation had immediately flared up. Intradermal test performed at 6 weeks after complete-recovery, was positive for cefotaxime.