Presentation: Cephalosporin-Induced Dress (Drug Rash with Eosinophilia and Systemic Symptoms) Syndrome in a 7-Year-Old Boy ( World Allergy Congress)

Thursday, 15 October 2015

Hall D1 Foyer (Floor 3) (Coex Convention Center)

Heejeong Kang, MD , Pediatrics, Soonchunhyang University College of Medicine, Seoul, South Korea

Taek-Ki Min, MD, PhD , Pediatrics, Soonchunhyang University College of Medicine, Seoul, South Korea

Hyeon-Jong Yang, MD, PhD , Pediatrics, Soonchunhyang University College of Medicine, Seoul, South Korea

Bok-Yang Pyun, MD, PhD. , Pediatrics, Soonchunhyang University College of Medicine, Seoul, South Korea

A 7-year-old boy with acute osteomyelitis in right distal tibia, was treated by the combination of intravenous (IV) vancomycin and cefotaxime. He was tolerable for the given treatment and rapidly improved. Persistent fever had occurred from the day 17th with pruritic, maculopapular rash on day 19^th. Laboratory test performed on day 20^th revealed marked eosinophilia. Under suspicion of DRESS syndrome, both IV antibiotics were stopped and oral prednisolone was given. Three days after the cessation of the antibiotics, fever and skin manifestations had rapidly improved. However, as soon as we retried IV cefotaxime, his skin manifestation had immediately flared up. Intradermal test performed at 6 weeks after complete-recovery, was positive for cefotaxime.

2017 Cephalosporin-Induced Dress (Drug Rash with Eosinophilia and Systemic Symptoms) Syndrome in a 7-Year-Old Boy