Presentation: Different Increases of Specific Immunoglobulin G4 By Different House Dust Mite Subcutaneous Immunotherapy Reagents ( World Allergy Congress)

Friday, 16 October 2015

Hall D1 Foyer (Floor 3) (Coex Convention Center)

Kyung Hee Park, MD , Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea

Hye Jung Park, MD , Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea

Jae-Hyun Lee, MD, PhD , Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea

Jung-Won Park, MD, PhD , Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea

Sangchul Lee, MD , Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea

Background: Specific immunoglobulin G₄ (sIgG₄) produced by subcutaneous immunotherapy (SCIT) has critical role of induction of allergen tolerance. However, comparative studies of available SCIT reagents on the induction of sIgG4 are limited. We compared the increase of sIgG4 by 3 different kinds of house dust mite (HDM) SCIT reagents.

Methods: Seventy-one HDM sensitized allergic patients were enrolled and classified into 4 groups including one control (n=27), SCIT using Hollister-Stier^®(n=18, maintenance dose = 750.8±255.3 Allergy Unit), Tyrosine S^®(n=16, maintenance dose 14,999.4±2854.4 TU), and Novo-helisen^®(n=10, maintenance dose = 3057.1±1268.7 TU). Maintenance dose of Hollister-Stier was determined by the physician, and the other 2 reagents by the provided companies. Specific IgE and sIgG₄ to Dermatophagoides farina were measured before and at 13.7 ± 6.54 months after the beginning of SCIT using ImmunoCAP^® system.

Results: Mean level of specific IgG₄ to Dermatophagoides farina (Gd2) before SCIT was 0.39 ± 0.49 mg/L and found is no difference among the groups (P = 0.118). After SCIT, Gd2 level was significantly increased, but the increases were quite different according to the SCIT groups (p <0.001). Gd2 level was highest in Hollister-Stier^®(2.89 ± 1.88 mg/L) compared with Tyrosine S^® (0.67 ± 0.52 mg/L) and Novo-helisen^®(2.16 ± 2.31 mg/L). Specific IgE to Dermatophagoides farina after SCIT was increased in Hollister-Stier^® (12.53 ± 29.78 kU_A/L) and Tyrosine S^®(2.18 ± 16.34 kU_A/L), but decreased in Novo-helisen^® (-2.19± 27.20 kU_A/L) which were not significantly different. (p=0.429)

Conclusions: Currently available SCIT reagents induce different levels of specific IgG₄and maybe have different efficacy.

3122 Different Increases of Specific Immunoglobulin G4 By Different House Dust Mite Subcutaneous Immunotherapy Reagents