Presentation: Changes in Pulmonary Function in the Treatment of Obesity in Children ( World Allergy Congress)

Friday, 16 October 2015

Hall D1 Foyer (Floor 3) (Coex Convention Center)

Keigo Kainuma, MD , Mie National Hospital, Tsu, Mie, Japan

Takahiro Ito, MD , Allergy Center and Department of Clinical Research, Mie National Hospital, Tsu, Japan

Yu Kuwahara, MD , Allergy Center and Department of Clinical Research, Mie National Hospital, Japan

Junya Hirayama, MD , Allergy Center and Department of Clinical Research, Mie National Hospital, Japan

Mizuho Nagao, MD, PhD , Allergy Center and Department of Clinical Research, Mie National Hospital, Japan

Takao Fujisawa, MD, PhD , Allergy Center and Department of Clinical Research, Mie National Hospital, Tsu, Japan

Background： Associations between obesity and asthma in adults and children have been implicated but causal mechanisms, especially those related to respiratory physiology, are not well understood. We reported previously that obesity caused in abnormal reactance values in lung physiology. To further dissect the link, we analyzed changes in pulmonary function during the treatment of obesity in children.

Methods：Eleven obese children (9 boys and 2 girls) from 8 to 15 years of age were enrolled in this study. 3 of them were hospitalized for more over 3months and the others were outpatients for 6 months. Eight had no asthma and 2 of them had asthma in mild intermittent severity without need of controller medications. Spirometry and two forced oscillation technique (FOT) tests (MostGraph® and Master Screen IOS®) were performed to assess lung function before and after treatment of obesity (diet and exercise). Patients were divided into two groups, the success group (n=5) and the failure group (n=6), based on outcome in weight loss. Success was defined as more than 10% improvement in percentage of overweight (POW) in the observation period.

Results: In FOT, R5-R20, resonant frequency (Fres), reactance area (AX) (IOS®) and R5, Fres (MostGraph®) were significantly improved in the success group, not in the failure group. As previously reported, FEV1.0% was improved significantly in the success group, not in the counterpart.

Conclusions: Respiratory function, not only FEV1 but reactance and resistance parameters in FOT, was improved in parallel with weight loss in obese children, which may implicate functional relationship between obesity and asthma.

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