4009 The Hidden Culprit: A Case of Repeated Anaphylaxis from Cremophor Hypersensitivity.

Saturday, 17 October 2015
Hall D1 Foyer (Floor 3) (Coex Convention Center)

Sehyo Yune, MD , Department of Medicine, Samsung Medical Center, Seoul, South Korea

Jin-Young Lee, MD, PhD , Health Promotion Center, Samsung Medical Center, Seoul, South Korea

Jihye Kim, MD , Department of Medicine, Samsung Medical Center, Seoul, South Korea

Young Nam Kim, MD , Department of Medicine, Samsung Medical Center, Seoul, South Korea

Young Eun Kim , Department of Pharmacy, Samsung Medical Center, Seoul, South Korea

Yongseok Lee , Department of Pharmacy, Samsung Medical Center, Seoul, South Korea

Jae-Won Paeng , Samsung Biomedical Research Institute, Seoul, South Korea

Mi-Jin Jang , Samsung Biomedical Research Institute, Seoul, South Korea

Dong-Chull Choi, MD, PhD , Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

Byung-Jae Lee, MD, PhD , Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

Drug-induced anaphylaxis is a big pitfall in patients receiving antineoplastic chemotherapy. We report a case of lung cancer patient who experienced two near-fatal anaphylactic reactions that resulted from paclitaxel and multivitamin, separately. Recurrent severe reactions to different agents led to further investigation to which material the patient was hypersensitive. The skin prick test revealed sensitization to cremophor, which is a commonly used emulsifying agent. This case emphasizes the importance of correctly identifying the culprit drug of anaphylaxis to avoid potentially fatal reaction.
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