Saturday, 17 October 2015
Hall D1 Foyer (Floor 3) (Coex Convention Center)
Sang-Heon Kim, MD
,
Department of Internal Medicine, Hanyang University College of Medicine, Seoul, South Korea
Sang-Hoon Kim, MD
,
Department of Internal Medicine, Eulji University School of Medicine, Seoul, South Korea
Jang Won Sohn, MD
,
Department of Internal Medicine, Hanyang University College of Medicine, Seoul, South Korea
Ho Joo Yoon, MD
,
Department of Internal Medicine, Hanyang University College of Medicine, Seoul, South Korea
Dong Ho Shin, MD
,
Department of Internal Medicine, Hanyang University College of Medicine, Seoul, South Korea
Jae Hyung Lee, MD
,
Department of Internal Medicine, Eulji University School of Medicine, Seoul, South Korea
Byoung Hoon Lee, MD
,
Department of Internal Medicine, Eulji University School of Medicine, Seoul, South Korea
Youn-Seup Kim, MD
,
Department of Internal Medicine, Dankook University College of Medicine, Cheonan, South Korea
Jae-Seuk Park, MD
,
Department of Internal Medicine, Dankook University College of Medicine, Cheonan, South Korea
Young-Koo Jee, MD
,
Department of Internal Medicine, Dankook University College of Medicine, Cheonan, South Korea
Backgrounds: While the pathomechanisms of antituberculosis drugs (ATD)-induced hepatitis is poorly understood yet, a growing body of evidence supports roles of adaptive immune response in ATD-induced hepatitis. Costimulatory molecules have modulatory effects on activation of T cell, B cell and antigen presenting cell. We examined if the polymorphisms in costimulatory molecules (CD28, CTLA-4, CD40 and CD40L) are associated with ATD-induced hepatitis.
Methods: We enrolled 80 patients with ATD-induced hepatitis and 238 ATD-tolerant subjects. DNA was isolated from whole blood and genotyped for the single nucleotide polymorphisms (SNPs) in CD28, CTLA4, CD40 and CD40LG. Genotype frequencies of SNPs and haploptyes were compared between patients with ATD-induced hepatitis and ATD-tolerant patients.
Results: In selected SNPs of CD28 (rs3116496), CTLA4 (rs5742909, rs231775, rs3087243, rs17268364), CD40 (rs1800686, rs1883832) and CD40LG (rs3092952), genotype frequencies were not different between case and control subjects. In the analysis of haplotypes of CTLA4 and CD40LG genes, there was no significant relationship with ATD-induced hepatitis.
Conclusions: These findings indicate that genetic polymorphisms of costimulatory molecules (CD28, CTLA-4, CD40 and CD40L) are not associated with the development of ATD-induced hepatitis in Korean population, and suggest that co-stimulatory molecules do not play important roles in the pathogenesis of ATD-induced hepatitis.
