Methods: Patients with cough persisting for more than 8 weeks were prospectively enrolled. They were divided into two groups according to the presence of wheezing in the past. Results of methacholine bronchial challenge and induced sputum examination were compared between two groups.
Results:Four hundred sixty patients (165 men and 295 women) were enrolled and analyzed. Their mean age was 47.4 years and the median duration of cough was 13.5 months. Patients who had experienced wheezing were 164 (35.6%). The prevalence of CVA (36.4% vs. 5.8%, p<0.01) and NAEB (15.4% vs. 4.4%, p<0.01) were significantly higher in wheezing group compared to non-wheezing group.
Conclusion: History of wheezing in the past significantly increases the chance of CVA or NAEB in patients with chronic cough. Careful history taking is important in diagnosing the cause of chronic cough.