Saturday, 17 October 2015
Hall D1 Foyer (Floor 3) (Coex Convention Center)
Takahiro Ito, MD
,
Allergy Center and Department of Clinical Research, Mie National Hospital, tsu city, Japan
Yu Kuwahara, MD
,
Allergy Center and Department of Clinical Research, Mie National Hospital, Tsu, Japan
Junya Hirayama, MD
,
Allergy Center and Department of Clinical Research, Mie National Hospital, Tsu, Japan
Keigo Kainuma, MD
,
Allergy Center and Department of Clinical Research, Mie National Hospital, Tsu, Japan
Mizuho Nagao, MD, PhD
,
Allergy Center and Department of Clinical Research, Mie National Hospital, Tsu, Japan
Takao Fujisawa, MD, PhD
,
Allergy Center and Department of Clinical Research, Mie National Hospital, Japan
Objectives: Exercise-induced asthma (EIA) is a significant burden for children with bronchial asthma because EIA often interfere with exercise activities of children if it is not properly treated and children with uncontrolled EIA may fall into inactive, sedentary life. We hypothesized that daily activity of children with EIA can be improved by controlling EIA. To test the hypothesis, we evaluated physical activity in children with EIA before and after EIA-targeted therapy. “Achieve Active life by Controlling EIA for asthmatic Kids (ACE kids) study”.
Methods: We enrolled 7-10 years old boys with untreated EIA. The patients were eligible if they had current history of exercise-induced symptoms, >12%reduction in FEV1 by treadmill exercise challenge at entry and had no anti-inflammatory treatment. Physical activity of the subjects were monitored using an accelerometer, Lifecoder EX®(Suzuken), during 2 weeks of run-in period and 8 weeks of treatment with salmeterol/fluticasone combination (SFC). Primary outcome was the length of strenuous activity in a day and secondary outcomes were %fall in FEV1 after exercise challenge, peak flow and exhaled NO.
Results: Eight patients (mean 9.5 ± 0.6 years) were enrolled and 6 gave full dataset. The length of strenuous activity a day increased in 5 patients out of 6. Fall in FEV1 after exercise challenge was significantly smaller after treatment. Morning and evening peak flow significantly increased and exhaled NO significantly decreased after SFC.
Conclusions: EIA-targeted treatment for boys with EIA improved their physical activity and measurement of physical activity with an accelerometer may be a surrogate marker for asthma control in children.
