Presentation: Effectiveness of premedication and rapid desensitization in hypersensitivity to l-asparaginase ( World Allergy Congress)

Thursday, 15 October 2015

Hall D1 Foyer (Floor 3) (Coex Convention Center)

Hwan Soo Kim, MD , The Catholic University of Korea, Seoul, South Korea

Sul Mui Won , The Catholic University of Korea, Seoul, South Korea

Yoon Hong Chun, MD , The Catholic University of Korea, Seoul, South Korea

Jong-Seo Yoon, MD , The Catholic University of Korea, Seoul, South Korea

Hyun Hee Kim, MD , The Catholic University of Korea, Seoul, South Korea

Jin Tack Kim, MD , The Catholic University of Korea, Seoul, South Korea

Background:

L-asparaginase is a crucial chemotherapeutic agent for the treatment of acute lymphoblastic leukemia. However, hypersensitivity to L-asparaginase is common which limits its usage. We aimed to evaluate the usefulness of premedication and desensitization in L-asparaginase hypersensitivity.

Methods

We performed 44 cases premedication and 3 cases of desensitization in 16 patients with hypersensitivity to L-asparaginase.

Results

With premedication, 33 cases completed L-asparaginase injection with no hypersensitivity reaction. 11 cases showed mild hypersensitivity reaction, such as urticaria. Desensitization was performed in 3 cases: 2 cases were successful and in 1 case, medication was switched to Erwinia asparaginase.

Conclusion

Premedication and desensitization appears to be useful in helping patients receive desired dose of L-asparaginase in pediatric patients with acute lymphoblastic leukemia.

2002 Effectiveness of premedication and rapid desensitization in hypersensitivity to l-asparaginase