Objective: The aim of this study was to assess the cause and clinicopathologic findings of injection-induced dermatitis, and to reveal whether the reaction have any relations in the age, site, concentration of the drugs, and time interval from injection of drug to occurrence of skin lesion.
Methods: This study enrolled 10 patients who had erythematous skin lesion after injection of causative drugs. The lesions are compared to each other based on the site, time interval from injection of drug to occurrence of skin lesion, and clinical characteristics. We perforemed intradermal test and patch test to each patient with different concentration of causative drugs.
Results: The most common causative drugs were diclofenac and vitamin K1. Eczematous type was the most frequent clinical feature. Intradermal test showed more positive results than the patch test. Patch test with diclofenac (as is, 2.5%, 5%, and 10%) and vitamin K1 10% were all negative in 10 patients. And intradermal tests with diclofenac as is and vitamin K1 (0.1%, 1%, and 10%) were performed in 8 patients. Six patients had a positive reaction, consisting of erythema, induration and vesiculation after 1 and 2 days.
Conclusions: In these results, most common causative agents were found as diclofenac and vitamin K1. And, it seems that intradermal test is more useful in the diagnosis of injection-induced dermatitis.