Objective: We sought to evaluate the association between CRS and HRQoL after adjustment for confounding factors in the general adult Korean population. We also evaluated HRQoL according to presence of NP in CRS patients.
Methods: In this cross-sectional study we used nationally representative samples from the 5th Korea National Health and Nutrition Examination Survey (2010–2012). A total of 17,490 participants were included in the study, of which 613 were diagnosed with CRS. Univariate analysis was conducted on healthy versus CRS groups, segregated by gender with weighted prevalence of demographic characteristics, socioeconomic status, and comorbid diseases. Subanalysis was carried out to evaluate the relationship between CRS with or without NP and HRQoL using EuroQol 5-Dimension (EQ-5D). The odds ratios for EQ-5D were estimated by multiple logistic regression analyses with confounder adjustment.
Results: Weighted prevalence of CRS of adult male participants was found to be 3.7% and CRS with nasal polyps (CRSwNP) 0.5%, while female CRS was 3.3% and CRSwNP 0.3%. There was no significant difference between the groups (P =0.3321). The scores for female, EQ-5D index (P for trend <0.0001) and EQ-VAS (P for trend =0.0024) showed decreasing trend from healthy participants to CRS without nasal polyps (CRSsNP) and from CRSsNp to CRSwNP. After adjusting for demographic characteristics, socioeconomic status, and comorbid diseases, EQ-5D scores; EQ-5D index (P <0.0001) and EQ-VAS (P <0.0001) exhibited poorer HRQoL compared to healthy participants, exclusively within the female group.
Conclusion: These data suggest that female patients with CRS are at higher risk of poor HRQoL. In addition, HRQoL of female CRSwNP was lower compared to those of CRSsNP and healthy participants.