1491 Clinical characteristics of patients undergoing allergoid sublingual immunotherapy. a retrospective study (part II)

Wednesday, 8 December 2010
Background and Method

235 subjects underwent allergoid sublingual Immunotherapy (Lofarma S.p.A., Italy) (SLIT) for rhinitis (RI), asthma (AS) with or without conjunctivitis (OC+/-). We describe relationships between sex (M–F), pathology, mono (MS) or polysensitivity (PS), seasonal (Ss) or perennial (Pr) SLIT. Results

SLIT regarded 230 RI (98.3%) including 151 AS (RI+AS) (65.6%), and 4 AS (1.7%): so 155 AS (66.2%), 97.4 % RI+, 86 (RI+AS) were OC+ (57%), 45 RI ( 57%) and 1 AS (25%): OC links to RI. The 145 M (61.9%) and F, the 200 PS (85.4%) and 34 MS, had similar age (28.3-32.3 ) and also similar MS in M-F (20-14;13.8-15.7%) (p>0.38). Considering casual the 4 AS, 3 M PS (OC-) and 1 F MS (OC+), higher  M prevailed also in  pathology and (Ss) or (Pr) SLIT: 44/79 RI (55.7%),  98/151 (RI+AS) (64.9%) being M-RI  4/8 MS (50%) and 40/71 PS (56.3%) and M-(RI+AS), 16/25 MS (64%) and 82/126 PS (65.1%). In  the 235 SLIT, 1 double in a M PS, M were 146/235 (62.1%), 20/34 MS (58.8%) and 126/201 PS (62.7%) (p=0,68) being M Ss SLIT, total or MS or PS, respectively 84/131(64.1%), 9/15 (60%) and 75/116 (64.6%) and M Pr-ITS respectively 62/104 (59.6%), 11/19 (57.9%) e 51/85 (60%). In Ss SLIT were 131 (55,7%): 84/146 M (57.5%) and 47/89 F (52.8%); higher in  PS 116/201 (57.7%), M 75/126 (59.5%), F 41/75 (54.7%), whereas in MS prevailed Pr SLIT, total 19/34 (55.9%), if M 11/20 (55%) or F 8/14 (57.1%) (p=0,2). Higher prevalence of RI+AS interested both sexes: in 145 M,  20 MS e 125 PS, respectively 98 (67.6%), 16 (80%) and 82 (65.6%), where RI was 44 (30.3%), 4 (20%) e 40 (32%); in 89 F, 14 MS e 75 PS,  respectively 53 (67.6%), 44 ( 80%) and 9 (65.6%), with RI 35 (39.3%), 4 (38.6%) and 31 (41.3%): globally a little higher prevalence of M (RI+AS), and of F RI particularly if MS. Similar findings were found relating  (RI+AS) to Ss or Pr SLIT if MS and PS. Conclusions

SLIT selection seems independent from sex, pathology and kind of sensitivity and is suitable for all seasonal antigens.