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234 subjects living in a subalpine region underwent allergoid sublingual immunotherapy (Lofarma S.p.A., Italy) (SLIT) during 5 years for allergic oculorinitis and/or asthma unresponsive to pharmacologic treatments. We describe relationships between sex (M–F), age, average prick tests (PK) antigens (Ag) reactivity, Ag)/histamine wheal (1+<0,25 doubling to 4+>2), for perennial (Pr) or seasonal (Ss) Ag, mono (MS) or polysensitivity (PS), and formulations in tablets (TB) or drops (DP). Results
19 Ag were tested (mean 16; range 9-19) always including 7: birch, grass mix (GR), mugwort, Parietaria mix (PAR), Alternaria alternata, Dermatophagoydes farinae (DF) and cat dander (CT).
The 145 M (61.9%) and 89 F had similar age (28.3-29.8; range 6-56; ds12.6) and MS (20-14) (13.8-5.7%) (p>0.38).5 Ag reacted the more, average GR 2.5 + DF-Dermatophagoides pteronyssinus (DERM) (1.9-1.7+), hazelnut-birch (BET) (1.3-1.4+), the same in M and F (p>0.05). BET-PAR reactivity increases with age, DERM-GR decreases, lower only for GR in MS (0.7+) than in PS (2.9+) (p<0.001). 34 MS (14.5%) and 200 PS had similar age (32.3-28.3; ds15.6-11.8) and higher M prevalence (20-125; 58.8-62.5%) (P>0,05) too ; M-MS increases with age (odds 5.6; p=0.05), not F-MS or M-F PS (p=0.7). Reflecting PK reactivity MS-Ag (Pr) SLIT were higher, 19 DERM (55.9%), than (Ss), 9 BET (26.5%) and 6 GR (17.6%); but PS-Ag (Pr) SLIT lower (p=0.2): 81 DERM (40.5%) and 4 KT (2%), 93 GR (46.5%), including 40 (43%) BET associations and 9 PAR (9.7%); BET alone 16 (8%), 3 PAR, 2 Cupressus and 1 each mugwort and ragweed. The total SLIT were 130 Ss SLIT (55.6%), 114 (48.7%) GR and/or BET, BET globally 56 (23.9%), 100 DERM SLIT (42.7%). TB-SLIT were 173 (73.9%): 98 DERM (56.6%), 46 GR (26.6%), 21 BET (12.1%), 4 KT (1.2%), than 2 PAR, and 1 each mugwort and ragweed. The 61 DP SLIT were 40 associations: GR+BET (65.6%), 9 GR+PAR (14.7%), 2 Cupressus (3.28%) and 10 GR, BET, DERM or PAR. Conclusions
In a subalpine region trees and DERM are important antigens. The high need for GR+BET SLIT lead to think to common antigens. TB are often prescribed while DP imply particular antigens or associations.