Occupational asthma in petrochemistry workers with persistant exposure

Background: To evaluate the effect of treatment with Fluticasone / Salmeterol combination on respiratory symptoms and pulmonary function tests ( PFT ) in petrochemistry workers with occupational asthma (OA) and persistant exposure  in work place.

Method: 40 workers with known history of OA enrolled in this study.Twice daily inhalation therapy with Fluticasone propionate ( 500 mcg ) and Salmeterol ( 50 mcg ) was initiated. At the enrollment and every 3 months, PFT and respiratory symptom score (RSS) were checked for one year period. Need for emergency use of salbutamol also was recorded .

Results: Mean baseline FEV1 was 80% of predicted values, but no statistically significant differences  in FEV1 and RSS were seen compare to baseline values after one year treatment.

Conclusion : Regular use ofcombination therapy with inhaled corticosteroids and long-acting bronchodilators can prevent respiratory symptoms deterioration over one year period in petrochemistry workers with occupational asthma and persistant exposure in work place.