Efficacy of sub-lingual immunotherapy in pollen allergic asthma

objective: The aim of this paper is to studying the efficacy of pollen sublingual immunotherapy in allergic asthmatic patients due to grass pollens  in two consecutive seasons .Methods: A randomized, double-blind, placebo-controlled search was done to evaluate the efficacy, carry-over effect and safety of grasses pollens with (SLIT).We enrolled 41 patients and 14 placebo patient with age rang was between ( 18 – 50 ) years . During a 11- day dose progression phase, the patients received a daily Successively increased  doses ( 10 – 20 – 40 – 60 – 80 – 100 – 300 – 600 – 1200 – 1800 – 2400 IR ) followed by 2400 IR three times every week in two consecutive seasons. Primary efficacy variables were symptoms and medication scores, and secondary variables included global evaluation of efficacy.  Results: There was a statistically improvement in SLIt treated patent in comparison with placebo group P(0,001).Side effects  were mainly local without any systemic side effects, five patients had sublingual itching and one patient had sneezing which  was  resolved with continuing therapy. Conclusion: Sublingual swallow immunotherapy seems to be safe and efficacious for allergic asthmatic patients due to Grass pollen even when started immediately or during pollen season.          

Key Words : Pollen , Grasses . Immunotherapy , Treatments