Asthma is a common and heterogeneous respiratory disease, usually associated with increased levels of total IgE, even in subjects negative for specific IgE to common aeroallergens.
To identify the relationship between total and specific IgE levels in school age Asthmatic children, determine the frequency of total IgE in related to age, family history and gender in asthmatic children, clarify the relationship between specific IgE levels and asthma, residence, and age, furthermore ; determine the frequency of asthmatic children in relation to family history, age, gender and residence.
This study was conducted at the Allergy and Asthma Center – Baghdad, 499 children with mild intermitted asthma of both genders included in this study, divided into 3 age groups (6-10, 11-14, and 15-19) years submitted to a questionnaire with evaluation of both total IgE and specific IgE antibodies to House Dust Mite levels.
The results were arranged in figures and tables and given as mean ± SD, values and data were analyzed using SPSS version 14. The differences between the study's groups were tested by using (ANOVA). P < 0.05 was accepted as statistically significant.
Male children were 270 (54%), 229 (46%) were female children, 290 of them live in urban area while only 209 live in rural area, There is a significant relationship between SD of specific IgE levels and total IgE in asthmatic children with a P value (0.000) and this relationship were significant in relation to positive family history with a p value= 0.003.
Even Many Population studies have shown an association between prevalence of asthma and total serum immunoglobulin E (IgE) levels independent of specific reactivity to common allergens, this study found that there is a significant relationship between the total IgE levels and the specific IgE levels in asthmatic children and both total IgE and specific IgE levels are high in asthmatic children with positive family history of asthma.