Sunday, 7 December 2014
Exhibition Hall-Poster Area (Sul America)
Edna Marques Araújo Silva, PhD
,
Clinical Toxicological Analysis, Federal University of Rio Grande Do Norte, Natal, Brazil
Sarah Dantas Viana Medeiros, PhD
,
Clinical Toxicological Analysis, Federal University of Rio Grande Do Norte, Natal, Brazil
Luanda Bárbara Ferreira Canário Souza
,
Clinical Toxicological Analysis, Federal University of Rio Grande Do Norte, Natal, Brazil
Vanessa Marques Araújo Silva, MD
,
Clinical Toxicological Analysis, Federal University of Rio Grande Do Norte, Natal, Brazil
Tereza Neuma De Souza Brito, PhD
,
Clinical Toxicological Analysis, Federal University of Rio Grande Do Norte, Natal, Brazil
Paula Renata Lima Machado, PhD
,
Clinical Toxicological Analysis, Federal University of Rio Grande Do Norte, Natal, Brazil
Valéria Soraya De Farias Sales, PhD
,
Clinical Toxicological Analysis, Federal University of Rio Grande Do Norte, Natal, Brazil
Background: This study investigated the relationship between total IgE and
Ascaris lumbricoides specific IgE
and eosinophils in children from endemic areas to assess the Th2-type immune response in a population that comprised 205 children with aged 1-10 years, and of low socioeconomic status.
Methods: Fecal samples were analysed by the methods of Blagg and Kato-katz. The serum levels of total IgE and A. lumbricoides specific IgE were determinated by ImmunoCAP (Pharmacia) and the eosinophils were counted in peripheral blood.
Results: The results showed a prevalence of 89% (182) for intestinal parasites. A. lumbricoides was detected in 140 (68%) children. The levels of total and specific IgE and eosinophils presented values above those of standard reference (median 480 KU/L and 0,74 KUA/L and 8%, respectively). Total IgE, A. lumbricoides specific IgE and eosinophils were significantly higher in the A. lumbricoides positive children as compared to A. lumbricoides negative ones (p = 0.02, <0.01 and 0.03).
Conclusions: Our results showed that parasites intestinal infection, particularly A. lumbricoides, induced a Th2-type immune response with production of the total and specific IgE and eosinophils.
