Methods: Series of cases involving 15 children over 4 years and adolescents who still had anaphylaxis to cow's milk. Specific IgE levels were evaluated in three steps of OIT: at baseline, pre-treatment session (step 1); When the patient reached the concentration 1:1 (step 2); and when reaching the final volume to 150 ml of milk a day (step 3). The differences between the levels of specific IgE were analyzed by Student's t test. The adopted level of significance was <0.05
Results: The age mean of the sample was 8.73 years (min: 4, Max: 19), 9 females. At step 1, the mean for specific IgE levels for milk; casein , α-lacto albumin and B-lacto albumin were respectively : 43,96 KU/L (Min:9,0 KU/l;Max: 100,0 KU/L); 31,35 KU/L (Min:7,0 KU/l;Max: 69,3 KU/L); 18,663 KU/L (Min:1,0 KU/l;Max: 45,5 KU/L) and 10,247 KU/L (Min:2,3 KU/l ; Max: 29,7 KU/L). At step 3, these values were respectively of 19,48 KU/L (Min:2,70 KU/l ;Max: 46,20 KU/L); 17,29 KU/L (Min:1,80 KU/l ; Max: 45,5 KU/L); 2,046 KU/L (Min:0,0 KU/l and Max: 29,5 KU/L) and 4,91 KU/L (Min:1,0 KU/l;Max: 17,0 KU/L). The compare of the mean of specific IgE levels between the steps 1 and 3 reached statistical significance for all antigens: milk (p<0,001); casein ( p=0,003); α-lacto albumin (p=0,002) and B-lacto albumin (p=0,005).
Conclusions: OIT to anaphylactic CMA reduces the specific IgE levels for milk proteins in parallel to developing of clinical tolerance to high volumes of milk ingestion.