José Ângelo Rizzo, PhD
,
Research Center for Allergy and Clinical Immunology, Hospital Das Clínicas - Universidade Federal De Pernambuco., Recife, Brazil
Marcelo José C N Silva Filho
,
'pós Graduação Em Ciências Da Saúde, Hospital Das Clínicas - Universidade Federal De Pernambuco., Recife, Brazil
Edil De Albuquerque Rodrigues Filho, Pt
,
Pneumology, Pos-Graduação Em Ciências Da Saúde - HC Ufpe, Recife, Brazil
Adriana Velozo Gonçalves
,
Pneumology, Pós-Graduação Em Ciências Da Saude, HC Ufpe, Recife, Brazil
Emanuel Sarinho, PhD
,
Federal University of Pernambuco, Brazil
Décio Medeiros, PhD
,
Research Center for Allergy and Clinical Immunology, Federal University of Pernambuco, Recife, Brazil
Almerinda Rego Silva, MD
,
Allergy and Clinical Immunologr, Hospital Das Clínicas - Universidade Federal De Pernambuco., Recife, Brazil
Marcelo José C N Silva Filho
,
'pós Graduação Em Ciências Da Saúde, Hospital Das Clínicas - Universidade Federal De Pernambuco., Recife, Brazil
Edil De Albuquerque Rodrigues Filho, Pt
Adriana Velozo Gonçalves
Décio Medeiros, PhD
,
Research Center for Allergy and Clinical Immunology, Federal University of Pernambuco, Recife, Brazil
Emanuel Sarinho, PhD
,
Research Center for Allergy and Clinical Immunology, Federal University of Pernambuco, Recife, Brazil
Almerinda Rego Silva, MD
,
Allergy and Clinical Immunologr, Hospital Das Clínicas - Universidade Federal De Pernambuco., Recife, Brazil
Background: Exercise induced bronchoconstriction (EIB) is the acute and transient increase in lower airway resistance that follows vigorous exercise and occurs in 50% to 90% of asthmatics. Objective methods for EIB diagnosis are required, usually by serial FEV1 after exercise challenge, usually treadmill running (TR). Eucapnic Voluntary Hyperventilation (EVH) is a recommended surrogate to TR for EIB diagnosis, although its clinical utility in young asthmatic is not established. Our objective was to compare both challenge methods for EIB diagnosis in asthmatic children and adolescents.
Methods: Were studied 34 asthmatics between 8 and 18 years of age from the Allergy clinic of the Hospital das Clínicas (Recife/Brazil) between September and December/2013. All underwent a basal FEV1 determination followed by TR for 8 minutes or EVH for 6 minutes in subsequent days, the first test randomly chosen. Serial FEV1 determinations at 3,5,7,10,15 and 30 minutes after the challenges were done. Were considered positive for bronchospasm only those individuals with a FEV1 fall > 10% from basal values in two consecutive tests.
Results: Thirteen patients had EIB after both challenges; six only after TR and four exclusively after Hiso (κ = 0,41, p <0.05). There were no differences in FEV1 fall intensity between both challenge techniques at any time interval. There was no difference in FEV1 fall intensity in any moment of evaluation between tests and a FEV1 fall > 30% was observed in only 2 patients after EVH and in 3 after TR, readily reversed by 400mcg albuterol inhalation.
Conclusions: EVH is safe and can be adopted as an alternativechallenge method, although it is necessary to evaluate its repeatability and compare with that of TR. Asthmatic children and adolescents with respiratory complaints after exercise but a negative test should have a second examination to exclude EIB.
