Presentation: Quality of life and disease activity assessment in patients with chronic urticaria (WAO International Scientific Conference 2014)

Sunday, 7 December 2014: 18:10 - 18:30

Exhibition Hall-Poster Area (Sul America)

Gabriela Andrade C Dias, MD, MSc , Internal Medicine, State University of Rio De Janeiro, Rio de Janeiro, Brazil

Fernanda Cunha Coelho, MD , State University of Rio De Janeiro, Rio de Janeiro, Brazil

Carolina Pennaforte, MD , State University of Rio De Janeiro, Rio de Janeiro, Brazil

Fabiana Caputo, MD , State University of Rio De Janeiro, Rio de Janeiro, Brazil

Priscilla Filippo Alvim De Minas Santos, MD , State University of Rio De Janeiro, Rio de Janeiro, Brazil

Anna Carolina Nogueira Arraes, MD , Internal Medicine, State University of Rio De Janeiro, Rio de Janeiro, Brazil

Denise Lacerda Pedrazzi, MD , Internal Medicine, State University of Rio De Janeiro, Rio de Janeiro, Brazil

Maria Ines Perelló, MD , Internal Medicine, State University of Rio De Janeiro, Rio de Janeiro, Brazil

Eduardo Costafsilva, MD, MSc, PhD , Asthma Comission, Brazillian Association of Allergy and Immunology, Rio de Janeiro, Brazil

Background: Chronic urticaria (CU) is a debilitating disease that affects patients’ quality of life (QoL) and the only questionnaire developed specifically to CU is the Chronic Urticaria Quality of Life Questionnaire (CU-Q₂oL). The aim of this study was to evaluate the QoL of patients with CU and to correlate it with disease activity.

Methods: The Brazilian Portuguese version of the CU-Q₂oL was self-administered in 96 adults with CU treated at the outpatient clinic of a university hospital. Disease activity was assessed using the Urticaria Activity Score (UAS). The following characteristics were also studied: age, gender, type of urticarial and duration of disease. ANOVA was used to compare the results of CU-Q₂oL between the different groups. The relationship between the CU-Q₂oL total score and dimensions and the UAS score was assessed by Pearson correlation coefficient.

Results: The study population comprised 85% women, with a median age of 46.5 years (IQR: 31-58.5) and median disease duration period was 19 months (IQR: 9.25-60). The main diagnosis was chronic spontaneous urticaria (CSU) (55.2%), with 21.9% associated with physical urticaria (PU); 18.8% had chronic autoimmune urticaria (CAIU), with 11.4% associated with PU, 27.1% had PU alone and 53.1% presented dermographic urticaria. Mean UAS score was 1.52±1.73 (0-6). The total CU-Q₂oL mean score was 33.39±21 (0-100) and dimension I (sleep/mental state/feeding) had the greatest impact on QoL. The items with the highest mean score were about itching (59) and nervousness (58) and the lowest were about eye edema (34) and sports activities’ limitations (35). The analysis of variance showed that women had greater impairment of quality of life in the dimensions I and III (edema/limitations/appearance) (p=0.02; p=0.01). Patients with CAIU and PU are more affected in total score and in all dimensions (p=0.005; p=0.008; p=0.04; p=0.008). The CU-Q₂oL was moderate correlated with UAS (r=0.45) (p<0.000) and was able to discriminate between patients with different degrees of disease severity.

Conclusions: CU patients’ have severely impaired QoL and a significant emotional burden. This study showed that women and patients with CAIU associated with PU had the greatest QoL impact. CU-Q₂oL and UAS are important instruments not only in research, but also to evaluate treatment outcomes and must be used in clinical practice.

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