1061 Selective IgA deficiency and sarcoidosis: A case report

Sunday, 7 December 2014
Exhibition Hall-Poster Area (Sul America)

Denise Lacerda Pedrazzi, MD , Internal Medicine, State University of Rio De Janeiro, Rio de Janeiro, Brazil

Barbara Felix V. De Vasconcellos, MD , State University of Rio De Janeiro, Rio de Janeiro, Brazil

Fernanda Fragoso Guia, MD , State University of Rio De Janeiro, Rio de Janeiro, Brazil

Samara Covre Santana, MD , State University of Rio De Janeiro, Rio de Janeiro, Brazil

Gabriela Andrade C Dias, MD, MSc , Internal Medicine, State University of Rio De Janeiro, Rio de Janeiro, Brazil

Maria Ines Perelló, MD , Internal Medicine, State University of Rio De Janeiro, Rio de Janeiro, Brazil

Anna Carolina Nogueira Arraes, MD , Internal Medicine, State University of Rio De Janeiro, Rio de Janeiro, Brazil

Eduardo Costafsilva, MD, MSc, PhD , Asthma Comission, Brazillian Association of Allergy and Immunology, Rio de Janeiro, Brazil

Background:

Selective IgA deficiency is the most common humoral immunodeficiency. It's defined as serum IgA levels lower than 7mg/dl in individuals above four years old, and with normal values of IgM and IgG. There are also significant association between IgA isolated deficiency and autoimmune diseases. Few cases have been reported in the literature of the coexistence of sarcoidosis and IgA deficiency. The aim of this study was to report a case of this association.

Methods:

A descriptive case study of a patient monitored in the outpatient clinic of Immunodeficiencies at a university hospital and a brief review of the literature.

Results:

LMM, female, 52 years old, was admitted to the outpatient clinic of Immunodeficiencies on February 20th/2013 with a previous diagnosis of selective IgA deficiency. It was done on June/2010 when the investigation of uveitis without other signs and symptoms showed a blood IgA level < 7mg/dl changes in chest tomography compatible with sarcoidosis. She had 3 or more sinusitis per year and also recurrent urinary tract infections. She underwent surgery for cataract secondary to uveitis without complications and at the moment she is well and with no complaints. Selective IgA deficiency can be asymtomatic or can show a wide spectrum of clinical manifestations. The main clinical complaints that suggest its diagnosis are recurrent infections, severe allergic reactions and association of diseases with possible autoimmune mechanism, such as rheumatoid arthritis, systemic lupus erythematosus, thyroiditis and kidney diseases, which occur more frequently. Therefore it is recommended a clinical and laboratory work-up for the development of autoantibodies.

Conclusions:

In this case report, selective IgA deficiency was diagnosed during the investigation of an autoimmune disease not frequently associated with it, reinforcing the need of a wide immunologic work-up in every autoimmune condition.