Methods: We report a case of drug rash induced by levothyroxine and currently oral desensitization.
A 31 year-old woman had been diagnosed as Hashimoto´s Thyroiditis. She was having levothyroxine for 9 years when she begun to present bilateral eyelids maculopapular rash. Blood exams and physical examination were normal except for the eyelids´ rash.
As she stopped using levothyroxine, the rash has disappeared.
Her endocrinologist prescribed her other brands of levothyroxine, and the patient reported the same reaction.
Results: Therefore, we performed an oral desensitization with multiple doses of the drug preparation. The procedure was started at a dose of 1,00µg. Every 30 minutes the dose was increased until a total dose of 127,00µg.
After 2 months, she currently tolerates 100,00µg/d.
Conclusions: It is unusual that biological substances induce allergic reactions when given exogenously.
Once it happens, drug desensitization can be performed at a hospital by experienced professionals with satisfactory response.