Methods: 86 Patients with features of Mild Bronchial Asthma and Allergic Rhintis {Skin prick test for House Dust Mite -D.Farinae and D. Pteronyssinus were positive} were divided in to 2 groups. 48 Patients received Sublingual drops of purified standard Allergen Extract preparation over the period of 3 yrs.. other group of 38 were given placebo for the same period..At the end of 3 yrs and 4 yrs assessment of Clinical efficacy done.. The following parameters like Symtoms Medication Score, Pulmonary Function study and Repeat Skin Prick test were considered for the assessment.
Results: Group of Patients treated with House Dust Mite extracts showed significant reduction in Symptom Medication score at the end of 3 and 4 yrs. .Also showed significant improvement in FEV1 and FVC at the end 3 and 4 yrs.. Skin Prick test at the end of 3 yrs showd minimal reduction in Wheal diameter when comparing old Skin prick test...No significant side effects except few local (sublingual) reactions for initial few days of drops.
Conclusions: Sublingual Immunotherapy is effective and potential therapy for House Dust Mite Sensitive Allergic Rhinitis and Mild Bronchial Asthma and it is safer too.