3076 Isolated severe angioedema attacks during menstrual cycle

Tuesday, 9 December 2014
Exhibition Hall-Poster Area (Sul America)

Ali Kutlu, associated proff. , Allergy and Immunology, GATA Haydarpasa Teaching Hospital, Istanbul, Turkey

Neslihan Yerebasmaz, MD , Department of Obstetrics and Gynecology, Ankara Etlik Zubeyde Hanim, Spesialist in Obstetrics and Gynecology, Ankara, Turkey

Ersin Aydın , Department of Dermatovenereology, Kasimpasa Military Hospital, Specialist in Dermatovenereology, İstanbul, Turkey

Ercan Karabacak, assistant Proff. , Dermatology, Gata Haydarpasa Teaching Hospital, Istanbul, Turkey

İsmet Gün , Department of Obstetrics and Gynecology, GATA Haydarpasa Teaching Hospital, Spesialist on Obstetrics and Gynecology, İstanbul, Turkey

Sami Öztürk , Department of Allergy and Immunology, GATA Haydarpasa Teaching Hospital, Spesialist on Allergy and Immunology, İstanbul, Turkey


Background: Progesterone hypersensitivity (PH) is a rare clinical condition that displays hypersensitivity to endogenous or exogenous progesterone. It is characterized by cyclic dermatologic manifestations at the end of the luteal phase that disappear some days after menses.

Methods: We present a case of 24-year-old woman showing severe angioedema attacks occurring from the first day of her menstruation and continuing for 4-5 days. Regular antihistamine and leukotriene receptor antagonist medication before the  menstruation neither prevented angioedema attacks nor shortened their duration.Progesterone intradermal test (IDT) with 50 mg/ml was positive  but  5 mg/ml  was negative. Same results were observed with  a control group of 4 healthy and reproductive females

Results: Our patient was prescribed combination oral contraceptive Two months later, on the patient's control visit, she did not suffer from angioedema attack during the last two menstrual cycles when she used oral contraceptives

Conclusions: Diagnosis and treatment of PH, IDT tests with progesterone may give high rates of false positive results; and clinical picture and response to the treatment must be assessed primarily