Background: Progesterone hypersensitivity (PH) is a rare clinical condition that displays hypersensitivity to endogenous or exogenous progesterone. It is characterized by cyclic dermatologic manifestations at the end of the luteal phase that disappear some days after menses.
Methods: We present a case of 24-year-old woman showing severe angioedema attacks occurring from the first day of her menstruation and continuing for 4-5 days. Regular antihistamine and leukotriene receptor antagonist medication before the menstruation neither prevented angioedema attacks nor shortened their duration.Progesterone intradermal test (IDT) with 50 mg/ml was positive but 5 mg/ml was negative. Same results were observed with a control group of 4 healthy and reproductive females
Results: Our patient was prescribed combination oral contraceptive Two months later, on the patient's control visit, she did not suffer from angioedema attack during the last two menstrual cycles when she used oral contraceptives
Conclusions: Diagnosis and treatment of PH, IDT tests with progesterone may give high rates of false positive results; and clinical picture and response to the treatment must be assessed primarily