Immunological disorders in patients with spinal trauma

Background: the dynamics of immunological parameters after spinal trauma correlates with the state of resistance in the general adaptation syndrome and fits in the staged development of traumatic disease. The aim of the study was to assess the state of the immune system, by studying the quantitative composition of the main lymphocyte subpopulations in spinal trauma.

Methods: immunophenotyping basic lymphocytes  subpopulations in 49 patients with spinal trauma.

Results: Our studies have shown a 76% increase in the relative number of examinees CD3 + cells to 85.7% while the number of T-helper cells (CD4 +) increased to 59.1%. The level of CD8 +, CD56 +16 +, CD19 +, and activated cells expressing on their surface HLA-DR + receptors remained within the reference units.

Conclusions: in spinal trauma  in 76% of patients have a reaction from the immune system, manifested by cell-mediated syndrome characterized by an increase in the number of T-lymphocytes by helper cells, which could have a negative role on the stability of metal in the postoperative period.