Methods: We recruited 145 children including 45 atopic children with mycoplasma pneumonia (Group 1), 39 non-atopic children with mycoplasma pneumonia (Group 2), 35 children with viral pneumonia (group 3), 26 non-atopic children with viral pneumonia with mycoplasma infection (Group 4). The change of total eosinophil count, serum levels of interleukin (IL)-5, eosinophil cationic protein were measured at admission and at recovery for each group by using commercial ELISA.
Results: The serum level of IL-5 at admission was increased at recovery in group 1 (114±51.1 pg/mL at admission, 143.2±68.4 pg/mL at recovery). However, Buserum eosinophil cationic protein concentrations were increased at clinical recovery compared to the mean serum concentration at admission(49.5 pg/mL at admission, 37.9 pg/mL at recovery in group 1; 38.2 pg/mL at admission, 27.8 pg/mL at recovery).
Conclusions: The outcomes of the present study implied changes of eosinophil and its mediators during Mycoplasma infection may be associated with the mechanism by which the Mycoplasma pneumoniae contribute to the development of airway hypersensitivity.