Saturday, 8 December 2012
Hall 4 (HICC)
Sun-Young Yoon, MD
,
Division of Allergy and Clinical Immunology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
So Young Park, MD
,
Division of Allergy and Clinical Immunology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
Sujeong Kim, MD
,
Division of Allergy and Clinical Immunology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
Hyouk-Soo Kwon
,
Asan Medical Center, University of Ulsan College of Medicine, Division of Allergy and Clinical Immunology, Department of Internal Medicine,, Seoul, South Korea
Yun-Jeong Bae, MD
,
Health Medicine, Health Screening and Promotion Center, Asan Medical Center, Seoul, South Korea
Jaehyung Roh, MD
,
Bonghwa Hospital, Gyungsangbukdo, South Korea
You Sook Cho, MD, PhD
,
Division of Allergy and Clinical Immunology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
Tae-Bum Kim, MD, PhD
,
Division of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
Hee-Bom Moon, MD, PhD
,
Asan Medical Center, College of Medicine Ulsan University, South Korea
Background: Cephalosporin is one of the most commonly used beta-lactam antibiotics globally, and also a major offending agent of drug hypersensitivity along with penicillin. Cephalosporin skin test has been widely used in most hospitals in Korea. However, the validity of this test for prediction of immediate hypersensitivity has still not been well studied. Therefore, we conducted this study to determine the predictive validity of cephalosporin skin test prior to administration.
Methods: We prospectively conducted intradermal skin test with selected 1st, 2nd, and 3rd generation cephalosporins: ceftazol, cefotetan or cefamandol, ceftriaxone or cefotaxime or flomoxef, respectively. After skin test, one of the tested cephalosporins was intravenously administered for preoperative prevention of infection under careful observation, regardless of the skin test results.
Results: We recruited 1,125 patients who needed the use of preoperative cephalosporins. Eighty five patients (7.5%) showed positive skin test to at least one cephalosporin. However, none of these patients showed immediate hypersensitivity reactions. Two patients who showed generalized urticaria and itching sense had negative skin test. The test showed sensitivity of 0%, specificity of 92.4%, negative predictive value of 99.8%, and positive predictive value 0%.
Conclusions: Routine skin test of cephalosporin prior to its administration is not valid for predicting immediate hypersensitivity with low sensitivity and positive predictive value. This study is currently ongoing for enrollment of larger study group.
