Saturday, 8 December 2012
Hall 4 (HICC)
Raúl Lázaro Castro Almarales, MD
,
Allergens Department, National Center of Bioproducts (BIOCEN), Allergology and General Integral Medicine, La Habana, Cuba
Mirta Alvarez Castello, MD
,
Allergology Department, University Hospital General Calixto García, WAO Member, Cuban Society of Allergy , Asthma and Clinical Immunology, Member, Cuban Society of Immunology Member, Havana, Cuba
José Severino Rodríguez Canosa, MD
,
Allergen Service, University Hospital "General Calixto García", WAO Member, Cuban Society of Immunology, Cuban Society of Allergy, Asthma and Clinical Immunology, Havana, Cuba
Mercedes Ronquillo Díaz
,
Allergen Service, University Hospital "General Calixto García", Specialist Second Degree in Allergology, Cuba
Mayda González León, MD
,
Docent Polyclinic "Pedro Fonseca", Cuban Society of Integral General Medicine Member, Cuban Society of Allergy , Asthma and Clinical Immunology, Member, Cuban Society of Immunology Member,, Havana, Cuba
Mary Carmen Reyes Zamora, MD
,
Allergen, Biocen, Cuba
Maytee Mateo Morejón
,
Allergen, Biocen, Cuba
Background: Immunotherapy with mite allergens is effective both in rhinitis and asthma. However, injection immunotherapy carries a high risk of systemic adverse events, so, the sublingual route (SLIT) is being used more frequently. Efficacy of SLIT in asthma has been widely studied, however, in Cuba, the therapeutic effect of mite vaccines of
Dermatophagoides pteronyssinus (Dp),
D.siboney (Ds) and
Blomia tropicalis(Bt) has been demonstrated only in adults, but not children. This aim is to determinate adherence and tolerability of SLIT with mite allergen vaccines using different treatment schedules in asthmatic children.
Methods: One hundred and twenty children (2 to 15 years) with mild to moderate asthma were selected for each treatment schedule. Three dosing schedules were used: (1) maximum of 3 daily drops; (2): max. 5 drops and (3) max. 10 drops, all by sublingual route. Incremental updosing was used for 3 weeks. A maintenance dose of 2000 BU was used once a week for schedule 1 and twice a week for schedules 2 and 3, during 2 months. Standardized House Dust Mite allergen vaccines of Dermatophagoides pteronyssinus, D. siboney and Blomia tropicaliswere employed (VALERGEN, BIOCEN, Cuba).
Results: Adherence to treatment was above 90% for the three schemes with no statistically significant difference (p>0,08) among them. The patients tolerated the different dosing schedules without having to change the planned scheme. Only two patients reported local adverse reactions, classified both as grade I (mild tongue itching without medication).
Conclusions: Summarizing, all children tolerated the three schedules similarly and adherence was high.
