Methods: This was a cross-sectional study of 34 samples of atopic dermatitis patients attending the skin clinic of Hospital Universiti Sains Malaysia (HUSM) and Hospital Raja Perempuan Zainab II (HRPZ II), Malaysia. 34 samples of normal controls were taken from healthy people (those who were free from allergic history) in HUSM. The subjects of healthy controls and atopic dermatitis patients were defined through history taking by physician. 5 ml of blood were collected from the normal control subjects and patients . Then, the blood was centrifuged and analyzed for IL 31 using ELISA kits (Human IL 31 Duoset, RnD System). Independent T-test was used to compare the level of serum IL 31 between normal control subjects and patients with atopic dermatitis
Results: The result showed that there was no significant difference in IL 31 serum levels between non allergic (174.89 ± 33.08, n=34, p=0.082)and atopic dermatitis patients (16499.46 ± 9243.56, n=34). However, there was a trend towards a higher IL31 serum levels in atopic dermatitis patients.
Conclusions: The results of this study suggest that although the level of IL31 serum levels was higher, there was no significant difference in IL 31 serum levels between atopic dermatitis patients and non allergic control