Abstract
Background Atopic dermatitis (AD) mostly frequent occurred in infant and children. Intrinsic and extrinsic factor are important role in AD. Epidermal barrier injury and dysregulatory of immune system could be induced by vitamin D. The aim of study was to reveal relation in between of serum level of 25-hydroxyvitamin D with atopic dermatitis occurrence and severity in children.
MethodThis study was cross sectional study to 21 AD patient and 21 control. Serum level of 25-hydroxyvitamin D was measured by enzyme-linked immunosorbent assay (ELISA) and evaluating AD severity by using Severity Scoring of Atopic Dermatitis SCORAD.
ResultAcquired deficiency of 25-hydroxyvitamin D in 20 AD patient (95,2%), Otherwise control study was obtained 57,1%. Median rate 25-hydroxyvitamin D in AD patient is lower than control study 4,977 (0,009-23,672) ng/mL and 14,374 (0,256-91,711) ng/mL, p=0,002. Median rate 25-hydroxyvitamin D in mild, moderate and severe AD patients are 4,262 (0,009-23,672) ng/mL, 4,262 (0,009-23,672) ng/mL and 2,336 (0,058-9,780) ng/mL
Conclusionserum level of 25-hydroxyvitamin D in AD patient is lower significantly than control study, though there is no relationship 25-hydroxyvitamin D with severity AD (p>0,05).
Keyword : Atopic dermatitis, 25-hydroxyvitamin D, severity atopic dermatitis