Saturday, 17 October 2015
Hall D1 Foyer (Floor 3) (Coex Convention Center)
Jin Mo Ku
,
Kyung Hee University, Seoul, South Korea
Se Hyang Hong
,
Kyung Hee University, Seoul, South Korea
Sunre Kim
,
Kyung Hee University, Seoul, South Korea
Han-Seok Choi
,
Kyung Hee University, Seoul, South Korea
Hye Sook Seo
,
Kyung Hee University, Seoul, South Korea
Younghee Yun
,
Kyung Hee University Hospital at Gangdong, Seoul, South Korea
Bo-Hyoung Jang
,
Kyung Hee University, Seoul, South Korea
Seoung-Gyu Ko
,
Kyung Hee University, Seoul, South Korea
Yong Cheol Shin
,
Kyung Hee University, Seoul, South Korea
Background: Allergic rhinitis (AR) is an allergic inflammation of the nasal airways. The
Korean herbal medicine, So-Cheong-Ryong-Tang (SCRT) has been typically used for the treatment of AR for hundreds of years. In the present study, we investigated whether SCRT suppresses the progression of AR in animal model.
Methods: AR was induced by ovalbumin (OVA). Treatment with SCRT was assessed to study the effect of SCRT on AR in mice. Histological analysis, multiplex cytokine assay, blood analysis, cell viability assay, RT-PCR and Elisa assay were performed to verify inhibitory effect of SCRT on AR.
Results: SCRT reduced infiltration of inflammatory cells into nasal cavity. SCRT reduced infiltration of mast cells into nasal mucosa. SCRT reduced the levels of cytokines (IL-4 and LIF) in the serum. SCRT reduced the levels of leukocytes in the blood. SCRT decreased cell viability of HMC-1 cells and splenocyte. SCRT suppressed IL-4 level in HMC-1 cells and splenocyte cells in a dose dependent manner. SCRT suppressed IL-6 level and TNF-α level in splenocyte.
Conclusion: SCRT suppresses the progression of AR induced by OVA. SCRT might be a useful drug for the treatment of AR.
