3107 Study of Efficacy of Sublingual Immunotherapy (SLIT) in Cases of Severe Persistent Allergic Rhinitis

Friday, 16 October 2015
Hall D1 Foyer (Floor 3) (Coex Convention Center)

Subir Jain, M.B., B.S, D.L.O , Ear Nose Throat, Ent Centre, INDORE, India

Title: Study of efficacy of sublingual immunotherapy (SLIT) in cases severe persistent allergic rhinitis.
Purpose: To asses efficacy of sublingual immunotherapy[SLIT] in treatment of severe persistent allergic rhinitis in the age group from 7 years to 63 years of either sex.
Material & Method: 214 patient of severe persistent allergic rhinitis were included to asses efficacy of sublingual immunotherapy [SLIT]. These patients were regular in treatment for more than 36 months. Symptom score were recorded on regular intervals 1st at the beigning of SLIT, then at completion of 1st maintenance vial i.e. 3rd vial then at every next maintenance vial. All patients follow up done about 4 to 5 times during Sublingual immunotherapy[SLIT] at regular intervals. Rescue medications for exacerbations of symptoms during pollen seasons were also taken in to account.
Number of Aeroallergens included ranges from average of 2 to 4 allergens.Glycerinated aqueous allergenic extract from various allergens were taken as per their sensitivity pattern.Different Allergen extracts suspended in extracting fluid [coca solution] containing 50% glycerine i.p. according to w/v ratio. Usual concentrations were Initiation 1:500,build up 1:250,maintainance 1:100, 1:50, 1:20,1:10.
Result: In above study results were encouraging. In symptom score scale of 0 to 3.[0 no symptoms ,1 mild ,2 moderate,3 severe]All patients were having severe symptoms before starting of sublingual immunotherapy.At the completion of 36 months of sublingual immunotherapy.Out of 214 patients 144 patients were on score 1, 54 patients on score 2 and 16 patients on score 0.Number of rescue medications along with SLIT was remarkably reduced even during pollen season.
Conclusion: Sublingual immunotherapy showing promising results in cases of chronic allergic rhinitis.