Presentation: Synergistic Interaction Between Bronchiolitis and PM<sub>10</Sub> Is Modified By <I>IL-13</I> Polymorphism on Asthma Development: Replication from Cheer Study ( World Allergy Congress)

Friday, 16 October 2015

Hall D1 Foyer (Floor 3) (Coex Convention Center)

Young-Ho Jung, MD , Department of Pediatrics, Bundang CHA Medical Center, CHA University School of Medicine, Seongnam, South Korea

Song-I Yang, MD , Department of Pediatrics, Hallym University Sacred Heart Hospital, Anyang, South Korea

Byoung-Ju Kim, MD , University of Cincinnati College of Medicine, Cincinnati, OH

Ji-Won Kwon, MD , Seoul National University Bundang Hospital, Seongnam, South Korea

Hwan-Cheol Kim, MD , Department of Occupational & Environmental Medicine, Inha University Hospital, Incheon, South Korea

Jong-Han Leem, MD , Department of Occupational & Environmental Medicine, Inha University Hospital, Incheon, South Korea

Ju-Hee Seo, MD , Department of Pediatrics, Korea Cancer Center Hospital, Seoul, South Korea

Hyung Young Kim, MD , Department of Pediatrics, Pusan National University Yangsan Hospital, Yangsan, South Korea

So-Yeon Lee, MD , Department of Pediatrics, Hallym University Sacred Heart Hospital, Anyang, South Korea

Ho-Jang Kwon, MD , Preventive Medicine, Dankook University College of Medicine, Cheonan, South Korea

Hyo-Bin Kim, MD , Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, South Korea

Hyun-Ju Cho, MD , Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea

Rationale: Asthma is a disorder that is driven by interactions between genetic and environmental factors. The aim was to investigate the interactions between bronchiolitis, PM₁₀ exposure and IL-13polymorphism in the development of asthma from a longitudinal study.

Methods: The study population was derived from a prospective 2-year follow-up survey of Children’s Health and Environmental Research (CHEER). 5,443 children from 16 elementary schools in seven cities were enrolled in the CHEER. Parents of the participants were asked to respond to an International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire to evaluate the presence of allergic diseases and risk factors. IL-13 (rs20541) genotypes were determined by TaqMan assay. PM₁₀exposure was estimated by the kriging method.

Results: The parental history of asthma (adjusted odds ratio [aOR], 3.73; 95% confidence interval [CI], 2.63-5.31), and bronchiolitis history within the first 2 years of life (aOR, 4.77; 95% CI, 3.66-6.21) were independent risk factors for physician-diagnosed asthma. But high PM₁₀ exposure for recent 5 years was not significant. When past episodes of bronchiolitis and high exposure to PM₁₀ were combined, the prevalence of asthma was significantly increased (aOR, 5.28; 95% CI, 3.61-7.72; P for interaction=0.007), also increased risk of asthma especially in children with GA+AA type of IL-13 polymorphism (aOR, 4.13; 95% CI, 1.89-9.07; P for interaction=0.101). New asthma diagnosis during follow-up period increased with higher PM₁₀exposure and bronchiolitis history (aOR, 3.18; 95% CI, 1.49-6.80, Pfor interaction = 0.107).

Conclusions: PM₁₀ exposure and bronchiolitis history synergistically increased asthma risk and new development of asthma in children, particularly if they had the IL-13 (rs20541) polymorphism. These findings suggest that PM₁₀exposure and bronchiolitis in early life contribute to the development of asthma, especially in susceptible children.

Keywords: Bronchiolitis; Particulate matter;Asthma; Interleukin-13; Polymorphism

3069 Synergistic Interaction Between Bronchiolitis and PM10 Is Modified By IL-13 Polymorphism on Asthma Development: Replication from Cheer Study

3069 Synergistic Interaction Between Bronchiolitis and PM₁₀ Is Modified By IL-13 Polymorphism on Asthma Development: Replication from Cheer Study