Saturday, 17 October 2015
Hall D1 Foyer (Floor 3) (Coex Convention Center)
Gun-Woo Kim, MD
,
Division of Allergy and Clinical Immunology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea
Ju-Young Kim, MD
,
Regional Pharmacovigilance Center, Seoul National University Hospital, Seoul, South Korea
Jin Lee
,
Regional Pharmacovigilance Center, Seoul National University Hospital, Seoul, South Korea
Ji Young Lee
,
Regional Pharmacovigilance Center, Seoul National University Hospital, Seoul, South Korea
Ji Young Go
,
Regional Pharmacovigilance Center, Seoul National University Hospital, Seoul, South Korea
So Jung Park
,
Regional Pharmacovigilance Center, Seoul National University Hospital, Seoul, South Korea
Hyo-Soo Kim, MD, PhD
,
Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea
Sang-Heon Cho, MD, PhD
,
Division of Allergy and Clinical Immunology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea
Jung Gyu Han, MD, PhD
,
Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea
Hye-Ryun Kang, MD, PhD
,
Regional Pharmacovigilance Center, Seoul National University Hospital, Seoul, South Korea
Background: Coronary angiography (CAG) is a standard method for diagnosing coronary artery disease. Iodinated contrast media (ICM) used in CAG can induce both immediate and delayed hypersensitivity reactions. However, studies on delayed hypersensitivity reactions to ICM are relatively few and the reported incidence varies greatly. Therefore, we aimed to investigate the incidence and clinical features of ICM-induced delayed hypersensitivity reactions following CAG.
Methods: We prospectively monitored ICM-induced delayed hypersensitivity in patients who underwent CAG from February 2015 to May 2015 at the Seoul National University Hospital. The ICM agents used were iodixanol and iopamidol. Symptoms were monitored from one hour to three weeks after the completion of CAG.
Results: A total of 265 patients received CAG during the study period (mean age 63.6 years, male 70.5%). Delayed hypersensitivity reactions occurred in 35 patients (13.2%). The most common manifestation was skin rash (88.5%), followed by chest discomfort and gastrointestinal symptoms. The majority (87%) of the skin reactions were mild (involving < 25% of the body surface), mostly occurring within 3 days of CAG (within 24 hrs: 40%, between 1-3 days: 42.8%; more than 3 days: 17.1%). Subgroup analysis by ICM agent used, gender, and age did not show any significant differences in the reaction incidence or clinical manifestations.
Conclusions: The incidence proportion of delayed hypersensitivity reactions to ICM was 13.2%, which was higher than previously reported. To our knowledge, this is the first study in Korea to investigate the incidence of ICM-induced delayed hypersensitivity following CAG.
