2163 Prognostic Factors for Atopic Dermatitis in Spontaneously Born Babies from Low Socioeconomic Background

Thursday, 15 October 2015
Hall D1 Foyer (Floor 3) (Coex Convention Center)

Conny Tanjung, MD , Pediatric, Pantai Indah Kapuk Hospital, Jakarta, Indonesia

Sri Rezeki Hadinegoro , Pediatric, Faculty of Medicine, University of Indonesia, Indonesia

Damayanti Sjarif , Pediatric, Faculty of Medicine, University of Indonesia, Indonesia

Berthold Koletzko , Nutrition and Metabolic, Ludwig-Maximilians-University of Munich, Germany

Background. The incidence of atopic dermatitis has markedly increased in this recents recent years. Atopic dermatitis develops due to interacting genetic and environmental factors. There is a lack of information on predictors of atopic dermatitis in vaginally born babies in low-income populations.

Objective.To describe risk markers of atopic dermatitis for the occurrence of atopic dermatitis in low-income population in Indonesia.

 Methods.Prospective survival analysis study was done in babies born vaginally in Kemayoran Community Health Centre in Central Jakarta over a 10 months period. Occurrence of atopic dermatitis until the age of 10 months was diagnosed based on Hanifin-Rajka criteria.  Prognostic factors for the development of atopic dermatitis were analyzed by SPSS Statistic 20 using Kaplan-Meier test and Cox regression model with a level of significance < 0.05.

Results.Some 400 healthy term infant were enrolled into this study. Male-to-female ratio was 1.04:1. The mean age at of the onset of atopic dermatitis was 5.4 months (ranging from 1 until 10 months). Family income varied from only 15 to 769 US$/ month with a mean income of 150 US$. Atopic dermatitis occurred in 53 (13.3%). Smoking, number of people in the house  and number of siblings in the family were not  associated with the occurrence of atopic dermatitis in bivariate analysis.  Atopic family history, higher degree of mother’s education and not being exclusively breastfed predicted occurrence of atopic dermatitis.  In multivariate analysis only atopic family history (HR 5.0, 95% CI 2.3-10.9) and lower mother’s education (HR 0.5, 95% CI 0.2;0.9) were  identified as prognostic factors.

Conclusion.  Atopic family history and higher mother’s education are independent prognostic factors for the occurrence of atopic dermatitis in infants from low income population in Indonesia.